Faculty and Staff
|Title:||Associate Professor, Mechanical Engineering, Biomedical Engineering
|Department:||Mechanical Engineering, Biomedical Engineering
College of Engineering and Computing
Research Area 1: Interactions between implanted polymeric materials and soft tissues
My early work was focused on understanding soft tissue-material interactions for the purpose of optimizing surgical sealant performance. The publications that emerged from this line of inquiry impacted the field in two distinct ways. First, we provided the initial demonstration that adhesion is a tissue-specific phenomenon that can be exploited in advanced material design. Second, these and related publications established novel design strategies to enhance adhesion strength without compromising material biocompatibility – the power in these strategies is that they can be generalized across material systems and surgical sealant applications.
Research Area 2: Characterization, assessment, and modeling of endovascular technologies
Endovascular technologies such as drug-eluting stents, erodible scaffolds, and drug-coated balloons have steadily evolved over the past 40 years. Multidisciplinary research approaches are needed to design, optimize, and evaluate emergent devices, typically requiring consideration of hemodynamics, drug pharmacokinetics, material mechanics, and device degradation/erosion kinetics. To accommodate this inherent complexity in the face of rapid device development, regulatory agencies have begun to expect and nearly require predictive computational models which clearly explain the mechanism-of-action and potential risk of new technologies. To meet this field demand, our work has been focused on the development of finite element-based computational models and design/deployment strategies to facilitate the continued advancement of endovascular technologies and their safe introduction into clinical practice.
Research Area 3: Experimental and theoretical biomechanical studies on native and
engineered blood vessels
The identification of constitutive mechanical models of vascular tissue is essential for quantifying the local environment of mechanosensitive vascular cells in normal and disease states, understanding mechanically-mediated vascular tissue remodeling, and providing a basis for the engineering of vascular tissue substitutes. Publications in these areas have been impactful in terms of providing data and models for previously understudied yet critical regions of the circulatory system, applying continuum-mechanical principles to explain intra-vessel variations in geometry, properties, and composition, and introducing tissue-engineered constructs which exhibit enhanced matrix elaboration and thus potential as vascular substitutes.
- Ph.D., Bio- and Polymeric Materials Science and Engineering, Massachusetts Institute of Technology, 2009
- S.M., Materials Science and Engineering, Massachusetts Institute of Technology, 2007
- M.S., Bioengineering, Georgia Institute of Technology, 2004
- B.S., Mechanical Engineering, Georgia Institute of Technology, 2001
- Romito E, Doviak H, Hartstone-Rose A, Logdon CB, Freels PD, Shazly T, Spinale FG. Sonomicrometry-based analysis of post-myocardial infarction regional mechanics. Annals of Biomedical Engineering, 2016 Jul 13.
- Prim D, Zhou B, Hartstone-Rose A, Uline M, Shazly T, Eberth J. A mechanical argument for the differential performance of coronary artery grafts. Mech Behav Biomed Mater. 2016 Feb;54:93-105.
- Zhou B, Ravindran S, Ferdous J, Kidane A, Sutton M, Shazly T. Using Digital Image Correlation to Characterize of Local Strains on Vascular Tissue Specimens. J Vis Exp. 2016 Jan 24;(107)..
- Ferdous J, Kolachalama VB, Kolandaivelu K, Shazly T. Degree of bioresorbable vascular scaffold expansion modulates loss of essential function. Acta Biomater, 2015 Aug 12. S1742-7061
- Zhou B, Rachev A, and Shazly T. The biaxial active mechanical properties of the porcine primary renal artery. J Mech Behav Biomed Mater. 2015 Aug;48:28-37.
- Kolandaivelu K, O'Brien C, Shazly T, Edelman ER, Kolachalama VB. Efficient approximation of computationally intensive physiologic simulations through supervised learning on coarse mesh solutions. Journal of the Royal Society Interface. 2015 Mar 6;12(104):20141073.
- Shazly T, Rachev A, Lessner S, Argraves WS, Ferdous J, Zhou B, Moreira A, Sutton M. On the uniaxial ring test of tissue engineered constructs. Experimental Mechanics. January 2015, Volume 55, Issue 1, pp 41-51.
- Alshareef M, Krishna V, Ferdous J, Alshareef A, Kindy M, Kolachalama V, Shazly T. Effect of spinal cord compression on local vascular blood flow and perfusion capacity. PLoS One. 2014 Sep 30;9(9).
- Zhou B., Wolf L., Rachev A., and Shazly T. A structure-motivated model of the passive mechanical response of the primary porcine renal artery. Journal of Mechanics in Medicine and Biology. 2014 14:03
- Twal WO, Klatt SC, Harikrishnan K, Gerges E, Cooley MA, Trusk TC, Zhou B, Gabr MG, Shazly T, Lessner SM, Markwald RR, Argraves WS. Cellularized microcarriers as adhesive building blocks for fabrication of tubular tissue constructs. Ann Biomed Eng. 2013 Aug 14.
- Rachev A, Shazly T. A preliminary analysis of the data from an in vitro inflation-extension test can validate the assumption of arterial tissue elasticity. J Biomech Eng. 2013 Aug 1;135(8):84502-4.
- Rachev A, Greenwald S, Shazly T. Are geometrical and structural variations along the length of the aorta governed by a principle of "optimal mechanical operation? J Biomech Eng. 2013 Aug 1;135(8):81006-9.
- Kolachalama VB, Pacetti SD, Franses JW, Stankus JJ, Zhao HQ, Shazly T, Nikanorov A, Schwartz LB, Tzafriri AR, Edelman ER. Mechanisms of tissue uptake and retention in zotarolimus-coated balloon therapy. Circulation. 2013 May 21;127(20):2047-55.
- Wang J, Boutin KG, Abdulhadi O, Personnat LD, Shazly T, Langer R, Channick CL, Borenstein JT. Fully Biodegradable Airway Stents Using Amino Alcohol-Based Poly(ester amide) Elastomers. AdvHealthc Mater. 2013 Mar 25.
- Harris G, Shazly T, and Jabbarzadeh E. Deciphering the combinatorial roles of geometric, mechanical, and adhesion cues in regulation of cell spreading. PLoS One. 2013 Nov 25;8(11):e81113.
- Ferdous J, Kolachalama VB, Shazly T. Impact of polymer structure and composition on fully resorbable endovascular scaffold performance. ActaBiomater. 2013 Apr; 9(4):6052-61.
- Luckanagul J, Lee LA, Nguyen QL, Sitasuwan P, Yang X, Shazly T, Wang Q. Porous alginate hydrogel functionalized with virus as three-dimensional scaffolds for bone differentiation. Biomacromolecules. 2012 Dec 10;13(12):3949-58.
- Shazly T, Kolachalama VB, Ferdous J, Oberhauser JP, Hossainy S, Edelman ER. Assessment of material by-product fate from bioresorbable vascular scaffolds. Ann Biomed Eng. 2012 Apr;40(4):955-65.
- Jabbarzadeh E, Blanchette J, Shazly T, Khademhosseini A, Camci-Unal G, Laurencin CT. Vascularization of biomaterials for bone tissue engineering: current approaches and major challenges. Current Angiogenesis, 2012, 12: 180-191.
- Kalcioglu ZI, Qu M, Strawhecker K, Shazly T, Edelman ER, VanLandingham M, Smith J,VanVliet K. Dynamic and quasistatic mechanical characterization of hydrated biological tissues and tissue surrogate gels. Philosophical Magazine, 91: 7 (2011) pp. 1339-1355.