Current Research Projects
Katie Kathrein, Ph.D.
Assistant Professor
Department of Biology, College of Arts and Sciences
Research Goal:
Find approaches to restoring the function of a tumor suppressor using a zebrafish
model.
Associate Professor
Department of Drug Discovery and Biomedical Sciences, College of Pharmacy
Research Goal:
Overcoming in vivo resistance to chemotherapy in triple-negative breast cancer.
Assistant Professor
Department of Drug Discovery and Biomedical Sciences, College of Pharmacy
Research Goal:
Investigate Tyrosyl tRNA synthetase as a new target in Alzheimer’s and other neurodegenerative
diseases.
Assistant Professor
Department of Drug Discovery and Biomedical Sciences, College of Pharmacy
Research Goal:
Generate potent and selective DDX3 inhibitors for the treatment of neurodegeneration.
Prior Research Projects
Eugenia Broude, Ph.D.
Assistant Professor
Department of Drug Discovery and Biomedical Sciences, College of Pharmacy
Research Goal:
Develop new approaches to improving the efficacy of breast cancer therapy by combining
targeted drugs with novel transcription-regulating kinase inhibitors.
Mentors:
Hippokratis Kiaris, Ph.D.
Phillip Buckhaults, Ph.D.
Jing Fang, Ph.D.
Assistant Professor
Department of Drug Discovery and Biomedical Services, College of Pharmacy
Research Goal:
Targeting of Gq/11 and calcineurin for leukemia therapy
Mentors:
Igor Roninson, Ph.D.
Lorne Hofseth, Ph.D.
Mythreye Karthikeyan, Ph.D.
Assistant Professor
Department of Chemistry & Biochemistry, College of Arts and Sciences
Research Goal:
Validate and explore inhibin as a novel potential cancer target for antibody-based
and small-molecule drugs.
Mentors:
Igor Roninson, Ph.D.
Hippokratis Kiaris, Ph.D.
Michy Kelly, Ph.D.
Associate Professor
Department of Pharmacology, Physiology & Neuroscience, UofSC School of Medicine
Research Goal:
Identify the molecular mechanisms that control Phosphodiesterase 11A (PDE11A) transcription
and/or catalytic activity in order to reveal new opportunities for developing PDE11A-targeted
therapeutics.
Mentors:
Igor Roninson, Ph.D.
Jim Fadel, Ph.D.
Norma Frizzell, Ph.D.
Assistant Professor
Department of Pharmacology, Physiology & Neuroscience, UofSC School of Medicine
Research Goal:
Validate and explore a new metabolic target for genetic neuropathological diseases
associated with aberrant mitochondrial function.
Mentors:
Lawrence Reagan, Ph.D.
Peisheng Xu, Ph.D.
Assistant Professor
Department of Drug Discovery and Biomedical Sciences, College of Pharmacy
Research Goal:
Develop a highly selective and efficient system for drug delivery into the brain and
test this system in a model of Alzheimer’s disease.
Mentors:
Qian Wang, Ph.D.
Mark Kindy, Ph.D.
Michael Shtutman, Ph.D.
Assistant Professor
Department of Drug Discovery and Biomedical Sciences, College of Pharmacy
Research Goal:
Develop an anti-cancer drug that kills both dividing and non-dividing tumor cells,
while sparing normal tissues, by targeting coatomer protein complex.
Mentors:
Igor Roninson, Ph.D.
Kim Creek, Ph.D.