| Title | Authors | Journal | Year | Keywords (hidden column) |
|---|---|---|---|---|
| CDK7 Inhibition is Effective in all the Subtypes of Breast Cancer: Determinants of Response and Synergy with EGFR Inhibition | McDermott MSJ, Sharko AC, Munie J, Kassler S, Melendez T, Lim CU, Broude EV | Cells | 2020 | tag 1, tag2 |
| A Highly Potent TACC3 Inhibitor as a Novel Anti-cancer Drug Candidate | Akbulut O, Lengerli D, Saatci O, Duman E, Seker UOS, Isik A, Akyol A, Caliskan B, Banoglu E, Sahin O | Molecular Cancer Therapeutics | 2020 | |
| Targeting lysyl oxidase (LOX) overcomes chemotherapy resistance in triple negative breast cancer | Saatci O, Kaymak A, Raza U, Ersan PG, Akbulut O, Banister CE, Sikirzhytski V, Tokat UM, Aykut G, Ansari SA, Dogan HT, Dogan M, Jandaghi P, Isik A, Gundogdu F, Kosemehmetoglu K, Disdar O, Aksoy S, Akyol A, Uner A, Buckhaults PJ, Riazalhosseini Y, Sahin O | Nature Communications | 2020 | |
| TRB3 regulates skeletal muscle mass in food deprivation-induced atrophy | Choi RH, McConahay A, Silvestre JG, Moriscot AS, Carson JA, Koh HJ | The FASEB Journal | 2019 | |
| Role of transcription-regulating kinase CDK8 in colon cancer metastasis | Liang J, Chen M, Broude EV, Roninson IB | Oncotarget | 2019 | |
| Repurposing suramin for the treatment of breast cancer lung metastasis with glycol chitosan-based nanoparticles | Cheng B, Gao F, Maissy E, Xu P | Acta Biomaterialia | 2019 | |
| Structural insight into substrate and inhibitor discrimination by human P-glycoprotein | Alam A, Kowal J, Broude E, Roninson I, Locher KP | Science | 2019 | |
| Identification of Novel Protein Targets of Dimethyl Fumarate Modification in Neurons and Astrocytes Reveals Actions Independent of Nrf2 Stabilization | Piroli GG, Manuel AM, Patel T, Walla MD, Shi L, Lanci SA, Wang J, Galloway A, Ortinski PI, Smith DS, Frizzell N | Molecular & Cellular Proteomics | 2019 | |
| Human CST suppresses origin licensing and promotes AND-1/Ctf4 chromatin association | Wang Y, Brady KS, Caiello BP, Ackerson SM, Stewart JA | Life Science Alliance | 2019 | |
| Nicotinamide Augments the Anti-Inflammatory Properties of Resveratrol through PARP1 Activation | Yanez M, Jhanji M, Murphy K, Gower RM, Sajish M, Jabbarzadeh E | Scientific Reports | 2019 | |
| Acute and short-term administrations of delta-9-tetrahydrocannabinol modulate major gut metabolomic regulatory pathways in C57BL/6 mice | Oza M, Becker W, Gummadidala PM, Dias T, Omebeyinje MH, Chen L, Mitra C, Jesmin R, Chakraborty P, Sajish M, Hofseth LJ, Banerjee K, Wang Q, Moeller PDR, Nagarkatti M, Nagarkatti P, Chanda A | Scientific Reports | 2019 | |
| Identifying Cancers Impacted by CDK8/19 | Roninson IB, Gyorffy B, Mack ZT, Shtil AA, Shtutman MS, Chen M, Broude EV | Cells | 2019 | |
| HPV16-transformed human keratinocytes depend on SIX1 expression for proliferation and HPV E6/E7 gene expression | Hosseinipour M, Wan F, Altomare D, Creek KE, Pirisi L | Virology | 2019 | |
| Development of microparticles for controlled release of resveratrol to adipose tissue and the impact of drug loading on particle morphology and drug release | Isely C, Hendley MA, Murphy KP, Kader S, Annamalai P, Jabbari E, Gower RM | International Journal of Pharmaceutics | 2019 | |
| Systems-level Analysis Reveals Multiple Modulators of Epithelial-mesenchymal Transition and Identifies DNAJB4 and CD81 as Novel Metastasis Inducers in Breast Cancer | Uretmen Kagiali ZC, Sanal E, Karayel O, Polat AN, Saatci O, Ersan PG, Trappe K, Renard BY, Onder TT, Tuncbag N, Sahin O, Ozlu N | Molecular & Cellular Proteomics | 2019 | |
| The host response to poly(lactide-co-glycolide) scaffolds protects mice from diet induced obesity and glucose intolerance | Hendley MA, Murphy KP, Isely C, Struckman HL, Annamalai P, Gower RM | Biomaterials | 2019 | |
| Characterizing CDK8/19 Inhibitors through a NFκB-Dependent Cell-Based Assay | Li J, Ji H, Porter DC, Broude EV, Roninson IB, Chen M | Cells | 2019 | |
| Systemic Toxicity Reported for CDK8/19 Inhibitors CCT251921 and MSC2530818 Is Not Due to Target Inhibition | Chen M, Li J, Liang J, Thompson ZS, Kathrein K, Broude EV, Roninson IB | Cells | 2019 | |
| Thymidylate synthase maintains the de-differentiated state of triple negative breast cancers | Siddiqui A, Gollavilli PN, Schwab A, Vazakidou ME, Ersan PG, Ramakrishnan M, Pluim D, Coggins S, Saatci O, Annaratone L, Hm Schellens J, Kim B, Asangani IA, Rasheed SAK, Marchio C, Sahin O, Ceppi P | Cell Death & Differentiation | 2019 | |
| Inhibition of the Dead Box RNA Helicase 3 Prevents HIV-1 Tat and Cocaine-Induced Neurotoxicity by Targeting Microglia Activation | Aksenova M, Sybrandt J, Cui B, Sikirzhytski V, Ji H, Odhiambo D, Lucius MD, Turner JR, Broude E, Peña E, Lizarraga S, Zhu J, Safro I, Wyatt MD, Shtutman M | Journal of Neuroimmune Pharmacology | 2019 | |
| The Meisenheimer Complex as a paradigm in drug discovery: reversible covalent inhibition through C67 of the ATP binding site of PLK1 | Pearson RJ, Blake DG, Mezna M, Fischer PM, Westwood NJ, McInnes C | Cell Chemical Biology | 2018 | |
| Insulin Resistance as a Therapeutic Target in the Treatment of Alzheimer's Disease: A State-of-the-Art Review | Benedict C, Grillo CA | Frontiers in Neuroscience | 2018 | |
| hnRNPs binding to the axonal localization motifs of Nrn1 and HMGB1 mRNAs define growth-associated RNA regulons | Lee SJ, Oses-Prieto JA, Kawaguchi R, Sahoo PK, Kar AN, Rozenbaum M, Oliver D, Chand S, Ji H, Shtutman M, Miller-Randolph S, Taylor RJ, Fainzilber M, Coppola G, Burlingame AL, Twiss JL | Molecular & Cellular Proteomics | 2018 | |
| CDK8 selectively promotes the growth of colon cancer metastases in the liver by regulating gene expression of TIMP3 and matrix metalloproteinases | Liang J, Chen M, Hughes D, Chumanevich AA, Altilia S, Kaza V, Lim CU, Kiaris H, Mythreye K, Pena MM, Broude EV, Roninson IB | Cancer Research | 2018 | |
| Impact of nutrition on inflammation, taupathy, and behavioral outcomes from chronic traumatic encephalopathy | Yu J, Zhu H, Taheri S, Mondy W, Perry S, Kindy MS | Journal of Neuroinflammation | 2018 | |
| Deoxycholate fractionation of fibronectin (FN) and biotinylation assay to measure recycled FN fibrils in epithelial cells | Varadaraj A, Magdaleno C, Mythreye K | Bio-protocol | 2018 | |
| Mediator kinase CDK8/CDK19 drives YAP1-dependent BMP4-induced EMT in cancer | Serrao A, Jenkins LM, Chumanevich AA, Horst B, Liang J, Gatza ML, Lee NY, Roninson IB, Broude EV, Mythreye K | Oncogene | 2018 | |
| Inhibin is a novel paracrine factor for tumor angiogenesis and metastasis | Singh P, Jenkins LM, Horst B, Alers V, Pradhan S, Kaur P, Srivastava T, Hempel N, Győrffy B, Broude EV, Lee NY, Mythreye K | Cancer Research | 2018 | |
| Dually modified transmembrane proteoglycans in development and disease | Jenkins LM, Horst B, Lancaster CL, Mythreye K | Cytokine & Growth Factor Reviews | 2018 | |
| Structure of a zosuquidar and UIC2-bound human-mouse chimeric ABCB1 | Alam A, Kung R, Kowal J, Mcleod RA, Tremp N, Broude EV, Roninson IB, Stahlberg H, Locher KP | Proceedings of the National Academy of Sciences of the United States of America | 2018 | |
| Stress-Induced TRBP phosphorylation enhances its interaction with PKR to regulate
cellular survival 2018 Pilot Project Publication |
Chukwurah E, Patel RC | Scientific Reports | 2018 | |
| Dually modified transmembrane proteoglycans in development and disease | Jenkins LM, Horst B, Lancaster CL, Mythreye K | Cytokine & Growth Factor Reviews | 2017 | |
| Tris (1, 3-dichloro-2-propyl) phosphate disrupts dorsoventral patterning in zebrafish embryos | Dasgupta S, Vliet SM, Kupsco A, Leet JK, Altomare D, Volz DC | PeerJ | 2017 | |
| Succination of Protein Disulfide Isomerase Mitochondrial Stress and Endoplasmic Reticulum Stress in the Adipocyte During Diabetes | Manuel AM, Walla MD, Faccenda A, Martin SL, Tanis RM, Piroli GG, Adam J, Kantor B, Mutus B, Townsend DM, Frizzell N | Antioxidants & Redox Signaling | 2017 | |
| CDK8/19 Mediator kinases potentiate induction of transcription by NFκB | Chen M, Liang J, Ji H, Yang Z, Altilia S, Hu B, Schronce A, McDermott MSJ, Schools GP, Lim CU, Oliver D, Shtutman MS, Lu T, Stark GR, Porter DC, Broude EV, Roninson IB | Proceedings of the National Academy of Sciences of the United States of America
|
2017 | |
| TGF-β triggers rapid fibrillogenesis via a novel TβRIIdependent fibronectin-trafficking mechanism | Varadaraj A, Jenkins LM, Singh P, Chanda A, Snider J, Lee NY, Amsalem-Zafran AR, Ehrlich M, Henis YI, Mythreye K | Molecular Biology of the Cell | 2017 | |
| Identification of novel cancer therapeutic targets using a designed and pooled shRNA library screen | Oliver D, Ji H, Liu P, Gasparian A, Gardiner E, Lee S, Zenteno A, Perinskaya LO, Chen M, Buckhaults P, Broude E, Wyatt MD, Valafar H, Pena E, Shtutman M | Scientific Reports | 2017 | |
| Angiostatic actions of capsicodendrin through selective inhibition of VEGFR2-mediated AKT signaling and disregulated autophagy | Pan CC, Shah N, Kumar S, Wheeler SE, Cinti J, Hoyt DG, Beattie CE, An M, Mythreye K, Rakotondraibe LH, Lee NY | Oncotarget | 2017 | |
| Inhibition of CDK8 mediator kinase suppresses estrogen dependent transcription and the growth of estrogen receptor positive breast cancer | McDermott MS, Chumanevich AA, Lim CU, Liang J, Chen M, Altilia S, Oliver D, Rae JM, Shtutman M, Kiaris H, Gyorffy B, Roninson IB, Broude EV | Oncotarget | 2017 | |
| Transgenerational attenuation of opioid self-administration as a consequence of adolescent morphine exposure | Vassoler FM, Oliver DJ, Wyse C, Blau A, Shtutman M, Turner JR, Byrnes EM | Neuropharmacology | 2017 | |
| Cellular Model of p21-Induced Senescence | Shtutman M, Chang BD, Schools GP, Broude EV | Methods in Molecular Biology | 2017 | |
| IL-33 promotes growth and liver metastasis of colorectal cancer in mice by remodeling the tumor microenvironment and inducing angiogenesis | Zhang Y, Davis C, Shah S , Hughes D, Ryan JC, Altomare D, Pena MM | Molecular Carcinogenesis | 2017 | |
| Crystal structure of truncated human coatomer protein complex subunit ζ1 (Copζ1) | Lunev S, Semmelink MF, Xian JL, Ma KY, Leenders AJ, Domling AS, Shtutman M, Groves MR | Acta Crystallographica Section F | 2017 | |
| ADAR1 and PACT contribute to efficient translation of transcripts containing HIV-1
trans-activating response (TAR) element
2017 Pilot Project Publication |
Chukwurah E, Handy I, Patel RC | Biochemical Journal | 2017 | |
| Intranasal insulin in Alzheimer's Disease: Food for thought
2017 Pilot Project Publication |
Chapman CD, Schioth HB, Grillo C, Benedict C | Neuropharmacology | 2017 | |
| Tribbles 3 regulates protein turnover in mouse skeletal muscle
2017 Pilot Project Publication |
Choi RH, McConahay A, Jeong H, McClellan JL, Hardee JP, Carson JA, Hirshman MF, Goodyear LJ, Koh HJ | Biochemical and Biophysical Research Communications | 2017 | |
| Altering the Proteoglycan State of Transforming Growth Factor β Type III Receptor (TβRIII)/Betaglycan Modulates Canonical Wnt/β-Catenin Signaling | Jenkins LM, Singh P, Varadaraj A, Lee NY, Shah S, Flores HV, O'Connell K, Mythreye K | Journal of Biological Chemistry | 2016 | |
| PDE11A regulates social behaviors and is a key mechanism by which social experience sculpts the brain | Hegde S, Ji H, Oliver D, Patel NS, Poupore N, Shtutman M, Kelly MP | Neuroscience | 2016 | |
| Activation of Mitofusin2 by Smad2-RIN1 Complex during Mitochondrial Fusion | Kumar S, Pan CC, Shah N, Wheeler SE, Hoyt KR, Hempel N, Mythreye K, Lee NY | Molecular Cell | 2016 | |
| A novel double-negative feedback loop between miR-489 and the HER2-SHP2- MAPK signaling axis regulates breast cancer cell proliferation and tumor growth | Patel Y, Shah N, Lee JS, Markoutsa E, Jie C, Liu S, Botbyl R, Reisman D, Xu P, Chen H | Oncotarget | 2016 | |
| Gold Nanosphere Gated Mesoporous Silica Nanoparticle Responsive to Near-Infrared Light and Redox Potential as a Theranostic Platform for Cancer Therapy | Cheng B, He H, Huang T, Berr SS, He J, Fan D, Zhang J, Xu P | Journal of Biomedical Nanotechnology | 2016 | |
| Tribbles 3 inhibits brown adipocyte differentiation and function by suppressing insulin signaling | Jeong HW, Choi RH, McClellan JL, Piroli GG, Frizzell N, Tseng YH, Goodyear LJ, Koh HJ | Biochemical and Biophysical Research Communications | 2016 | |
| Succination is Increased on Select Proteins in the Brainstem of the NADH dehydrogenase (ubiquinone) Fe-S protein 4 (Ndufs4) Knockout Mouse, a Model of Leigh Syndrome | Piroli GG, Manuel AM, Clapper AC, Walla MD, Baatz JE, Palmiter RD, Quintana A, Frizzell N | Molecular & Cellular Proteomics | 2016 | |
| A Critical Role for the GluA1 Accessory Protein, SAP97, in Cocaine Seeking
2016 Pilot Project Publication |
White S, Ortinski P, Friedman SH, Zhang L, Neve R, Kalb RG, Schmidt HD, Pierce RC | Neuropsychopharmacology | 2016 | |
| Behavioral History of Withdrawal Influences Regulation of Cocaine Seeking by Glutamate
Reuptake
2016 Pilot Project Publication |
Zhou L, Anderson H, Arreola AC, Turner J, Ortinski PI | PLOS One | 2016 | |
| Arginyltransferase suppresses cell tumorigenic potential and inversely correlates with metastases in human cancers | Rai R, Zhang F, Colavita K, Leu NA, Kurosaka S, Kumar A, Birnbaum MD, Gyorffy B, Dong DW, Shtutman M, Kashina A | Oncogene | 2015 | |
| Cancer cell-selective killing polymer/copper combination | He H, Altomare D, Ozer U, Xu H, Creek K, Chen H, Xu P | Biomaterials Science | 2015 | |
| Epigenetic Regulation of GDF2 Suppresses Anoikis in Ovarian and Breast Epithelia | Varadaraj A, Patel P, Serrao A, Bandyopadhay T, Lee NY, Jazaeri AA, Huang Z, Murphy SK, Mythreye K | Neoplasia | 2015 | |
| Purification of high-quality RNA from synthetic polyethylene glycol-based hydrogels | Gasparian A, Daneshian L, Ji H, Jabbari E, Shtutman M | Analytical Biochemistry | 2015 | |
| Prefrontal microRNA-221 Mediates Environmental Enrichment-Induced Increase of Locomotor Sensitivity to Nicotine | Gomez AM, Altomare D, Sun WL, Midde NM, Ji H, Shtutman M, Turner JR, Creek KE, Zhu J. | The International Journal of Neuropsychopharmacology | 2015 | |
| Endoglin Regulation of Smad2 Function Mediates Beclin1 Expression and Endothelial Autophagy | Pan CC, Kumar S, Shah N, Bloodworth JC, Hawinkels LJ, Mythreye K, Hoyt DG, Lee NY | Journal of Biological Chemistry | 2015 | |
| Identification of novel genes that regulate androgen receptor signaling and growth of androgen-deprived prostate cancer cells | Levina E, Ji H, Chen M, Baig M, Oliver D, Ohouo P, Lim CU, Schools G, Carmack S, Ding Y, Broude EV, Roninson IB, Buttyan R, Shtutman M | Oncotarget | 2015 | |
| Dual secured nano-melittin for the safe and effective eradication of cancer cells. Journal of materials chemistry | Bei C, Bindu T, Remant KC, Peisheng X | Journal of Materials Chemistry B | 2015 | |
| The effect of glucose concentration and sodium phenylbutyrate treatment on mitochondrial bioenergetics and ER stress in 3T3-L1 adipocytes | Tanis RM, Piroli GG, Day SD, Frizzell N | Biochimica et Biophysica Acta | 2015 | |
| Expression of CDK8 and CDK8-interacting Genes as Potential Biomarkers in Breast Cancer | Broude EV, Gyorffy B, Chumanevich AA, Chen M, McDermott MS, Shtutman M, Catroppo JF, Roninson IB | Current Cancer Drug Targets | 2015 | |
| The Novel KV7.2/KV7.3 Channel Opener ICA-069673 Reveals Subtype-Specific Functional
Roles in Guinea Pig Detrusor Smooth Muscle Excitability and Contractility
2015 Pilot Project Publication |
Provence A, Malysz J, Petkov, GV | Journal of Pharmacology and Experimental Therapeutics | 2015 | |
| Triple-responsive expansile nanogel for tumor and mitochondria targeted photosensitizer delivery | He H, Cattran AW, Nguyen T, Nieminen AL, Xu P | Biomaterials | 2014 | |
| Identification of protein succination as a novel modification of tubulin | Piroli GG, Manuel AM, Walla MD, Jepson MJ, Brock JW, Rajesh MP, Tanis RM, Cotham WE, Frizzell N | Biochemical Journal | 2014 |