Faculty and Staff
Michael J. Ryan, Ph.D.
|Title:||Associate Chief of Staff - Research - Columbia VA Health Care System
Professor, Pharmacology, Physiology and Neuroscience
|Department:||Pharmacology, Physiology and Neurology
School of Medicine Columbia
|Phone:||803-776-4000, ext. 56670|
Shirley L. Buchanan Center
Building 9, Room 117c
University of Iowa
State University of New York College at Buffalo, Physiology & Biophysics
State University of New York College at Cortland, Biological Sciences
Chronic inflammation and immune system dysfunction play important roles in the development of hypertension, cardiovascular, and renal disease. The Ryan laboratory is interested in understanding the mechanistic links driving these relationships To accomplish this goal, we focus specifically on the autoimmune disorder systemic lupus erythematosus (SLE). Patients with autoimmune disorders including SLE, rheumatoid arthritis, and scleroderma are at significantly elevated risk for the development of hypertension and the associated cardiovascular and renal consequences. In addition, evidence suggests that some patients with primary hypertension have circulating autoantibodies similar to those found in patients with autoimmune diseases. Currently funded work in the laboratory is focused on understanding the interaction between autoantibodies with renal and vascular tissue, and how that interaction promotes the development of hypertension.